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生物質譜分析研究室

成員


吳志哲(Chih-Che Wu) 教授
(049)2910960 - 4961 (lab)4764
wcche@ncnu.edu.tw

 

BIOGRAPHICAL INFORMATION

CONTACT

Department of Applied Chemistry,                             

National Chi Nan University

1 University Rd., Puli, Nantou, 545 

Tel:+886-49-2910960 ext 4961

E-mail: wcche@ncnu.edu.tw

EXPERTISE&CURRENT INTERESTS

Physical Chemistry, Analytical Chemistry, Biological Mass Spectrometry, and Nanotechnology

Fabrication and characterization of functional nanostructures for their bio-applications using mass spectrometry and optical spectroscopy.

EDUCATION

Postdoctoral Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, (2003-2006)  Research Advisor: H.-C. Chang

Postdoctoral Fellow, Department of Chemistry, University of California, Berkeley,, (2004-2005)    Research Advisor: E.R. Williams

Ph.D., Department of Chemistry, National Taiwan University, (2003) Research Advisor: Y.T. Lee
B.S, Department of Chemistry, National Taiwan Normal University, (1996)

EXPERIENCE
National Chi Nan University

Professor, Department of Chemistry (2017-present)

Associate Professor, Department of Chemistry (2011-2017)

Assistant Professor, Department of Chemistry (2006-2011)

Taipei Municipal Liu-Kong Junior High School

Science Teacher (1996-1998)

INVITED LECTURES

Oral presentation at the 17th Meeting of Methods in Protein Structure Analysis, Sapporo, Japan, 2008 ; Invited lecture at the National Science Council Fall Workshop, Taichung, Taiwan, 2009 ; Invited lecture at the 2012 Annual Meeting of Chemical Society Located in Taipei, Tainan, 2012; Invited lecture at the 4th Asia Oceania Mass Spectrometry Conference and 10th TSMS conference, Taipei, Taiwan, 2013. ;Invited lecture at Department of Physic, National Dong Hwa University, Hualien, Taiwan, 2013; Invited lecture at Department of Physic, Tunghai University, Taichung, Taiwan, 2013 ; Oral presentation at the Orchid Taiwan-France joint workshop, Cachan, France, 2013. ; Invited lecture at the 11th annual conference of the Taiwan Society for Mass Spectrometry, Taichung, Taiwan, 2014 ; Invited lecture at the Taiwan Society for Mass Spectrometry Winter Workshop, ChaiYi, Taiwan, 2014. ;Oral presentation at the Institute of Chemistry, Chinese Academy of Sciences, Beijing, China, 2015. ; Invited lecture at the 5th WCMSC & BCEIA 2015, Beijing, China, 2015. ; Invited lecture at the 2015 Annual Meeting of Chemical Society Located in Taipei, Hualian, Taiwan, 2015.; Invited lecture at 6th WCMSC, San Antonia, TX, USA, 2016.

SELECT PUBLICATIONS

1.          Tsai, P.-C.; Epperla, C. P.; Huang, J.-S.; Chen, O. Y.; Wu, C.-C.; Chang, H.-C., Measuring Nanoscale Thermostability of Cell Membranes with Single Gold–Diamond Nanohybrids. Angew. Chem. Int. Ed. 2017, 56 (11), 3025-3030.

2.          Haziza, S.; Mohan, N.; Loe-Mie, Y.; Lepagnol-Bestel, A.-M.; Massou, S.; Adam, M.-P.; Le, X. L.; Viard, J.; Plancon, C.; Daudin, R.; Koebel, P.; Dorard, E.; Rose, C.; Hsieh, F.-J.; Wu, C.-C.; Potier, B.; Herault, Y.; Sala, C.; Corvin, A.; Allinquant, B.; Chang, H.-C.; Treussart, F.; Simonneau, M., Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors. Nat Nano 2017, 12 (4), 322-328.

3.          Li, H.-C.; Hsieh, F.-J.; Chen, C.-P.; Chang, M.-Y.; Hsieh, P. C. H.; Chen, C.-C.; Hung, S.-U.; Wu, C.-C.; Chang, H.-C., The hemocompatibility of oxidized diamond nanocrystals for biomedical applications. Sci. Rep. 2013, 3, 3044.

4.          Hsieh, C.-C.; Guo, J. Y.; Hung, S.-U.; Chen, R.; Nie, Z.; Chang, H.-C.; Wu, C.-C., Quantitative Analysis of Oligosaccharides Derived from Sulfated Glycosaminoglycans by Nanodiamond-Based Affinity Purification and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. Anal Chem. 2013, 85, 4342-4349

5.          Zeng, Y. Y.; Chen, H.-J.; Shiau, K. J.; Hung, S.-U.; Wang, Y.-S.; Wu, C.-C., Efficient enrichment of phosphopeptides by magnetic TiO2-coated carbon-encapsulated iron nanoparticles. Proteomics 2012, 12 (3), 380-390.

6.          Shiau, K. J.; Hung, S. U.; Lee, H. W.; Wu, C. C., Nanodiamond-based two-step sampling of multiply and singly phosphorylated peptides for MALDI-TOF mass spectrometry analysis. Analyst 2011, 136 (9), 1922-192.

7.          Chang, Y. C.; Huang, C. N.; Lin, C. H.; Chang, H. C.; Wu, C. C., Mapping protein cysteine sulfonic acid modifications with specific enrichment and mass spectrometry: An integrated approach to explore the cysteine oxidation. Proteomics 2010, 10, 2961-2971.

8.          Tzeng, Y. K.; Chang, C. C.; Huang, C. N.; Wu, C. C.; Han, C. C.; Chang, H. C., Facile MALDI-MS analysis of neutral glycans in NaOH-doped matrixes: Microwave-assisted deglycosylation and one-step purification with diamond nanoparticles. Anal Chem. 2008, 80, 6809-6814.

9.          Chang, C. K.; Wu, C. C.; Wang, Y. S.; Chang, H. C., Selective extraction and enrichment of multiphosphorylated peptides using polyarginine-coated diamond nanoparticles. Anal Chem. 2008, 80, 3791-3797.